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Bioavailability of Ionic Silver
Promotional claims made for ionic silver products describe it as having high bioavailability. Nothing could be farther from the truth. The Merck Manual makes it clear that bioavailability is the amount of unchanged drug that reaches the systemic circulation. To be bioavailable the substance being ingested must attain systemic circulation unchanged in form. Because silver ions are highly reactive they quickly form compounds in the body and therefore cannot remain unchanged. While it is the highly reactive nature of silver ions that provides its antimicrobial properties, it also causes the rapid formation of compounds and prevents the continued existence of silver ions inside the human body. Because silver ions cannot exist inside the human body the bioavailability is virtually nonexistent. Silver compounds such as silver chloride in the bloodstream provide no meaningful antimicrobial properties.
Searching for Silver Ions in The Bloodstream
A silver Ion Selective Electrode (ISE) is a scientific instrument that can detect the presence of silver ions in blood serum. An ISE is able to detect silver ions that have not combined to form compounds. Once a silver ion combines to form a compound such as silver chloride the ISE will not be able to detect it. Over the years attempts have been made to generate silver ions in vivo by applying a small DC current to a silver catheter inserted directly into the bloodstream. The process is called electrolysis and it can produce silver ions in water or in the bloodstream. The researchers were using an ISE to measure the concentration of silver ions downstream from their point of generation. They soon discovered that the silver ions were very short lived in the bloodstream and determined that the half-life was about 7.8 seconds. Because blood serum contains about 3900 ppm of chloride the silver ions were forming silver chloride and could no longer be detected by the ISE instrument. Since silver ions that are created in the bloodstream by electrolysis cannot survive there is no reason to believe that silver ions that enter the body by any other means could survive.